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GENE - TERM ANNOTATION REPORT

RGD ID: 2073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agxt
Name: alanine--glyoxylate and serine--pyruvate aminotransferase
Acc ID: DOID:12679
Term: nephrocalcinosis
Definition: A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.
Definition Source(s): MESH:D009397
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7363368554872ClinVarClinVar Annotator: match by term: Nephrocalcinosis

PMID:10960483, PMID:12777626, PMID:15327387, PMID:17460142, PMID:23229545, PMID:28893421, PMID:9192270
 ISORGD:7363368554872ClinVarClinVar Annotator: match by term: Nephrocalcinosis

PMID:10960483, PMID:19155213, PMID:23229545, PMID:28893421, PMID:8101040, PMID:9136629
 ISORGD:7363368554872ClinVarClinVar Annotator: match by term: Nephrocalcinosis

PMID:17495019, PMID:24055001, PMID:24718375, PMID:28893421
 ISORGD:7363368554872ClinVarClinVar Annotator: match by term: Nephrocalcinosis

PMID:28893421
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.