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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2072
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr2
Name: angiotensin II receptor, type 2
Acc ID: CHEBI:61014
Term: PD123319
Definition: An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively
Chemical ID: MESH:C073402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr2decreases activityEXP 6480464CTDPD 123319 results in decreased activity of AGTR2 proteinPMID:11509473 PMID:18388195
Agtr2decreases expressionEXP 6480464CTDPD 123319 results in decreased expression of AGTR2 mRNAPMID:9336375 PMID:9740612
Agtr2increases expressionEXP 6480464CTDPD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 proteinPMID:11893553
Agtr2multiple interactionsEXP 6480464CTD[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 proteinPMID:16982965 PMID:18300857 PMID:18388195 PMID:19151255
Agtr2multiple interactionsISOAgtr2 (Mus musculus)6480464CTDPD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]PMID:25446015
Agtr2multiple interactionsISOAGTR2 (Homo sapiens)6480464CTD[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 proteinPMID:15807884 PMID:18551021
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