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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2070
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr1adecreases expressionEXP 6480464CTDCyclosporine results in decreased expression of AGTR1A mRNAPMID:14659064
Agtr1amultiple interactionsEXP 6480464CTDCyclosporine inhibits the reaction [Adenosine Triphosphate results in decreased expression of AGTR1A mRNA]; Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]PMID:14659064 PMID:21464294
Agtr1adecreases expressionISOAGTR1 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of AGTR1 mRNAPMID:20106945 PMID:25562108
Agtr1adecreases methylationISOAGTR1 (Homo sapiens)6480464CTDCyclosporine results in decreased methylation of AGTR1 promoterPMID:27989131
Agtr1amultiple interactionsISOAGTR1 (Homo sapiens)6480464CTD[Cyclosporine co-treated with Cholic Acids] affects the expression of AGTR1 mRNAPMID:27344345
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