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GENE - TERM ANNOTATION REPORT

RGD ID: 2067
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Agrn
Name: agrin
Acc ID: GO:0045202
Term: synapse
Definition: The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s): GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agrnis_active_inISOAgrn (Mus musculus)1624291RGD PMID:16635246

PMID:16635246
Agrnlocated_inISOAgrn (Mus musculus)1624291RGD PMID:18230682

PMID:18230682
Agrnlocated_inIEAGO:00072131600115GOCGO_REF:0000108

GO_REF:0000108
Agrnlocated_inIDA 8554671UniProtPMID:12796478

 
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