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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpincreases expression EXP 152177911RGDN-nitrosodiethylamine increases expression of Afp protein in serum in rats 
Afpaffects expressionEXP 6480464CTDDiethylnitrosamine affects the expression of AFP mRNAPMID:19822196
Afpincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of AFP mRNA; Diethylnitrosamine results in increased expression of AFP protein; Diethylnitrosamine results in increased expression of AFP protein alternative formPMID:11818250 PMID:19394651 PMID:19446540 PMID:24012840 PMID:24060683 PMID:24632418 PMID:24954034 PMID:27565560 PMID:29458170 PMID:29698782 PMID:30779474 PMID:32302048 PMID:35437842
Afpmultiple interactionsEXP 6480464CTD1,2,4-triazole analog inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; [Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein; [Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP protein; brucine inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; citral inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; formylchromone analog inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; FR 118487 inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; myrrh resin analog inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]; piperlongumine inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP protein]; Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Rotenone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Silymarin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein alternative form]; thymoquinone inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]PMID:19394651 PMID:19446540 PMID:24012840 PMID:24060683 PMID:24632418 PMID:24954034 PMID:28414157 PMID:28693887 PMID:28935427 PMID:29458170 PMID:29923357 PMID:30779474 PMID:32302048 PMID:35113675 PMID:35437842
Afpdecreases expressionISOAFP (Homo sapiens)6480464CTDDiethylnitrosamine results in decreased expression of AFP mRNAPMID:21527772
Afpincreases expressionISOAfp (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of AFP mRNA; Diethylnitrosamine results in increased expression of AFP proteinPMID:15766596 PMID:24535843 PMID:29859236
Afpmultiple interactionsISOAfp (Mus musculus)6480464CTD[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of AFP mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; [Phenobarbital co-treated with Pregnenolone Carbonitrile co-treated with Diethylnitrosamine] results in increased expression of AFP mRNA; Diethylnitrosamine promotes the reaction [Carbon Tetrachloride results in increased expression of AFP mRNA]; Fosinopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Perindopril inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]; Sorafenib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]PMID:21391223 PMID:23288052 PMID:24535843 PMID:29859236 PMID:33398415
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