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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpdecreases expressionISOAFP (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of AFP mRNA; Arsenic Trioxide results in decreased expression of AFP proteinPMID:23382965 PMID:33634982
Afpincreases expressionISOAfp (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of AFP mRNAPMID:29767511
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