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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2065
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Afp
Name: alpha-fetoprotein
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Afpaffects bindingEXP 6480464CTDEstradiol binds to AFP proteinPMID:23013281 PMID:25349334 PMID:9748407
Afpincreases expressionEXP 6480464CTDEstradiol results in increased expression of AFP mRNAPMID:32145629
Afpmultiple interactionsEXP 6480464CTDDiethylstilbestrol inhibits the reaction [Estradiol binds to AFP protein]PMID:9748407
Afpincreases response to substanceISOAfp (Mus musculus)6480464CTDAFP protein results in increased susceptibility to EstradiolPMID:22720075
Afpmultiple interactionsISOAFP (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of AFP proteinPMID:18497072
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