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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grk2
Name: G protein-coupled receptor kinase 2
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grk2increases expressionEXP 6480464CTDPhenylephrine results in increased expression of GRK2 proteinPMID:28759639
Grk2multiple interactionsEXP 6480464CTDGRK2 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of AKT1 protein]; GRK2 protein affects the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]PMID:28759639
Grk2multiple interactionsISOGrk2 (Mus musculus)6480464CTD[Phenylephrine co-treated with ADRA1B protein] results in increased expression of GRK2 proteinPMID:11499749
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