Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 2060
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb2
Name: adrenoceptor beta 2
Acc ID: DOID:3083
Term: chronic obstructive pulmonary disease
Definition: An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both. (DO)
Definition Source(s): https://pubmed.ncbi.nlm.nih.gov/28513453/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/32745458/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/32800196/ "DO" "DO", https://www.nhlbi.nih.gov/health-topics/copd "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Adrb2 ISOADRB2 (Homo sapiens)4140935RGDDNA:SNPs: :rs1042717, rs1042718 (human) 
Adrb2 ISOADRB2 (Homo sapiens)4144899RGD  
Adrb2 ISOADRB2 (Homo sapiens)4145093RGDDNA:SNP: :p.R16G (human) 
Adrb2 ISOADRB2 (Homo sapiens)5129114RGD  
Adrb2disease_progressionISOADRB2 (Homo sapiens)4145086RGDprotein:decreased expression:blood, sputum, mononuclear cell 
Adrb2no_associationISOADRB2 (Homo sapiens)4145082RGDDNA:polymorphism: :p.Q27E (human) 
Adrb2severityISOADRB2 (Homo sapiens)4145080RGDDNA:SNP: :p.R16G (human) 
Adrb2severityISOADRB2 (Homo sapiens)4145095RGDDNA:SNPs: :p.R16G, p.Q27E (human) 
Go Back to source page   Continue to Ontology report