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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adrb1
Name: adrenoceptor beta 1
Acc ID: CHEBI:64022
Term: nebivolol
Definition: A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Chemical ID: MESH:D000068577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingEXP 6480464CTDNebivolol binds to ADRB1 protein

PMID:2462161
multiple interactionsEXP 6480464CTDNebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]

Nebivolol inhibits the reaction [Dihydroalprenolol binds to ADRB1 protein]

PMID:2462161
multiple interactionsISORGD:7312896480464CTDNebivolol inhibits the reaction [CGP 12177 binds to ADRB1 protein]

Nebivolol inhibits the reaction [cyanopindolol binds to ADRB1 protein]

PMID:12535855
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.