GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | increases cleavage | EXP | | 6480464 | CTD | Etoposide results in increased cleavage of PARP1 protein | PMID:17516866 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | Niacin deficiency affects the reaction [Etoposide results in increased cleavage of PARP1 protein] | PMID:17516866 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased cleavage of PARP1 protein | PMID:12690110 PMID:16014620 PMID:16807353 PMID:16844113 PMID:17935137 PMID:20457658 PMID:21801448 PMID:25447644 PMID:26259609 PMID:28507149 PMID:30890322 PMID:9454737 | Parp1 | increases degradation | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased degradation of PARP1 protein | PMID:8840993 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [trigonelline co-treated with Etoposide] results in increased cleavage of PARP1 protein; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; XAF1 protein affects the reaction [Etoposide results in increased cleavage of PARP1 protein] | PMID:16014620 PMID:16545138 PMID:16799960 PMID:16807353 PMID:17935137 PMID:20457658 PMID:21801448 PMID:28507149 PMID:30890322 PMID:33148531 PMID:8840993 PMID:9454737 | | ||||||||||||||||||||||
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