Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1increases expressionISOPARP1 (Homo sapiens)6480464CTDsulforaphane results in increased expression of PARP1 protein modified formPMID:33894213
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein; [sulforaphane co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[sulforaphane co-treated with Arsenic Trioxide] results in increased cleavage of PARP1 protein]PMID:22922937 PMID:29792947
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDsulforaphane inhibits the reaction [cyanoginosin LR results in increased cleavage of PARP1 protein]PMID:21684301
Go Back to source page   Continue to Ontology report