GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | affects expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Fenretinide affects the expression of PARP1 mRNA | PMID:16570282 | Parp1 | decreases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Fenretinide results in decreased cleavage of PARP1 protein | PMID:17159502 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Fenretinide results in increased cleavage of PARP1 protein | PMID:15735044 PMID:16407847 PMID:25246272 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; [Fenretinide co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Ascorbic Acid inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; BI D1870 inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Fenretinide promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; MAPK8 protein promotes the reaction [Fenretinide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; S-ethyl glutathione inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein] | PMID:16230421 PMID:16407847 PMID:17273769 PMID:25246272 | |
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