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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects expressionISOPARP1 (Homo sapiens)6480464CTDFenretinide affects the expression of PARP1 mRNAPMID:16570282
Parp1decreases cleavageISOPARP1 (Homo sapiens)6480464CTDFenretinide results in decreased cleavage of PARP1 proteinPMID:17159502
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDFenretinide results in increased cleavage of PARP1 proteinPMID:15735044 PMID:16407847 PMID:25246272
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; 2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; [Fenretinide co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Ascorbic Acid inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; BI D1870 inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Deoxyglucose inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; Fenretinide promotes the reaction [TNF protein results in increased cleavage of PARP1 protein]; MAPK8 protein promotes the reaction [Fenretinide results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; S-ethyl glutathione inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]; U 0126 inhibits the reaction [Fenretinide results in increased cleavage of PARP1 protein]PMID:16230421 PMID:16407847 PMID:17273769 PMID:25246272
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