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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1affects cleavageISOPARP1 (Homo sapiens)6480464CTDCelecoxib analog affects the cleavage of PARP1 proteinPMID:18485224
Parp1increases activityISOPARP1 (Homo sapiens)6480464CTDCelecoxib results in increased activity of PARP1 proteinPMID:12824303
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDCelecoxib results in increased cleavage of PARP1 proteinPMID:15572759 PMID:15911099 PMID:16123214 PMID:17612393 PMID:18202791 PMID:18485224 PMID:19665451
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[Atorvastatin co-treated with Celecoxib] results in increased cleavage of PARP1 protein; Celecoxib inhibits the reaction [Fluorouracil results in increased cleavage of PARP1 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased expression of PARP1 protein]; Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased expression of PARP1 protein]; TNFRSF10B mutant form inhibits the reaction [Celecoxib results in increased cleavage of PARP1 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of PARP1 protein]PMID:15572759 PMID:15688368 PMID:17461495 PMID:18172863
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDCelecoxib promotes the reaction [Dihematoporphyrin Ether results in increased cleavage of PARP1 protein]PMID:16230411
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