GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in decreased expression of PARP1 mRNA; [Chelating Agents binds to Copper] which results in increased cleavage of PARP1 protein; [Copper co-treated with Disulfiram] results in increased cleavage of PARP1 protein; [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; [NSC 689534 binds to Copper] which results in decreased expression of PARP1 mRNA; [NSC 689534 binds to Copper] which results in increased cleavage of PARP1 protein; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein] | PMID:17079463 PMID:20971185 PMID:23033007 PMID:24690739 PMID:29115570 PMID:30911355 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | [Disulfiram binds to Copper] which results in increased cleavage of PARP1 protein | PMID:24690739 | | ||||||||||||||||||||||
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