GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | affects response to substance | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | PARP1 protein affects the susceptibility to arsenite | PMID:22387748 | Parp1 | decreases activity | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | arsenite results in decreased activity of PARP1 protein | PMID:17011244 PMID:18707137 PMID:22387748 | Parp1 | decreases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | arsenite results in decreased cleavage of PARP1 protein | PMID:22387748 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | arsenite results in increased cleavage of PARP1 protein | PMID:20083129 PMID:22260869 | Parp1 | increases cleavage | ISO | Parp1 (Mus musculus) | 6480464 | CTD | arsenite results in increased cleavage of PARP1 protein | PMID:23396362 PMID:32980394 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of PARP1 protein | PMID:18392098 | Parp1 | increases oxidation | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | arsenite results in increased oxidation of PARP1 protein | PMID:34798142 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [arsenite results in decreased activity of PARP1 protein] which affects the localization of AIFM1 protein; [arsenite results in decreased activity of PARP1 protein] which affects the localization of CYCS protein; [arsenite results in decreased activity of PARP1 protein] which results in decreased chemical synthesis of Poly Adenosine Diphosphate Ribose; [arsenite results in decreased activity of PARP1 protein] which results in decreased cleavage of and results in decreased activity of CASP3 protein; [arsenite results in decreased activity of PARP1 protein] which results in decreased cleavage of and results in decreased activity of CASP7 protein; [arsenite results in decreased activity of PARP1 protein] which results in decreased cleavage of and results in decreased activity of CASP9 protein; acetovanillone inhibits the reaction [arsenite results in increased oxidation of PARP1 protein]; Curcumin promotes the reaction [arsenite results in increased expression of PARP1 protein]; TP53 mutant form inhibits the reaction [arsenite results in increased cleavage of PARP1 protein]; Zinc inhibits the reaction [arsenite results in decreased activity of PARP1 protein] | PMID:18392098 PMID:18707137 PMID:22260869 PMID:22387748 PMID:34798142 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | MIR190A affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]]; NFE2L1 alternative form affects the reaction [arsenite results in increased cleavage of PARP1 protein]; NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]; PHLPP1 protein affects the reaction [NFKB1 protein affects the reaction [arsenite results in increased cleavage of PARP1 protein]] | PMID:23396362 PMID:32980394 | | ||||||||||||||||||||||
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