GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of PARP1 mRNA | PMID:34747641 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin promotes the reaction [Camptothecin results in increased cleavage of PARP1 protein] | PMID:25843524 | Parp1 | affects expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of PARP1 mRNA | PMID:22574217 | Parp1 | affects expression | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of PARP1 mRNA | PMID:21570461 | Parp1 | increases expression | ISO | Parp1 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of PARP1 mRNA | PMID:19465110 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [3-aminobenzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [3-aminobenzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]; [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [benzamide results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NAD]; [coumarin results in decreased activity of PARP1 protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased abundance of NADP]; Tetrachlorodibenzodioxin results in increased ADP-ribosylation of and results in increased activity of PARP1 protein | PMID:17669606 | Parp1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PARP1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PARP1 promoter] | PMID:17942748 PMID:19654925 | | ||||||||||||||||||||||
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