GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | decreases cleavage | EXP | | 6480464 | CTD | Estradiol results in decreased cleavage of PARP1 protein | PMID:24894866 | Parp1 | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of PARP1 mRNA | PMID:32145629 | Parp1 | multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Estradiol results in decreased cleavage of PARP1 protein] | PMID:24894866 | Parp1 | increases cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased cleavage of PARP1 protein | PMID:21732360 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein; [Estradiol promotes the reaction [PARP1 protein binds to HTR1A promoter mutant form]] which results in decreased expression of HTR1A mRNA; [Estradiol results in increased expression of PARP1 mRNA] which results in increased susceptibility to Cisplatin; [Estradiol results in increased expression of PARP1 mRNA] which results in increased susceptibility to Doxorubicin; Estradiol promotes the reaction [PARP1 protein binds to HTR1A promoter mutant form]; fulvestrant inhibits the reaction [Estradiol results in increased cleavage of PARP1 protein]; SB 203580 inhibits the reaction [[ESR2 protein results in increased susceptibility to Estradiol] which results in increased cleavage of PARP1 protein] | PMID:21732360 PMID:21990073 PMID:28323900 | | ||||||||||||||||||||||
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