Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2053
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Parp1
Name: poly (ADP-ribose) polymerase 1
Acc ID: CHEBI:136004
Term: linsidomine
Definition: null
Chemical ID: MESH:C002385
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Parp1decreases activityISOPARP1 (Homo sapiens)6480464CTDlinsidomine results in decreased activity of PARP1 proteinPMID:31152818
Parp1decreases expressionISOParp1 (Mus musculus)6480464CTDlinsidomine results in decreased expression of PARP1 proteinPMID:12880480
Parp1decreases foldingISOPARP1 (Homo sapiens)6480464CTDlinsidomine results in decreased folding of PARP1 proteinPMID:31152818
Parp1increases cleavageISOPARP1 (Homo sapiens)6480464CTDlinsidomine results in increased cleavage of PARP1 proteinPMID:34519134
Parp1multiple interactionsISOPARP1 (Homo sapiens)6480464CTD[bosutinib co-treated with linsidomine] affects the expression of PARP1 protein; bosutinib affects the reaction [linsidomine results in increased cleavage of PARP1 protein]; linsidomine inhibits the reaction [PARP1 protein binds to Zinc]; linsidomine results in decreased activity of and results in increased nitrosation of PARP1 proteinPMID:31152818 PMID:34519134
Parp1multiple interactionsISOParp1 (Mus musculus)6480464CTDSelegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein]PMID:12880480
Go Back to source page   Continue to Ontology report