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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Adm
Name: adrenomedullin
Acc ID: CHEBI:6413
Term: letrozole
Definition: A triazole that has formula C17H11N5.
Chemical ID: MESH:C067431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Admincreases expressionEXP 6480464CTDLetrozole results in increased expression of ADM proteinPMID:33491863
Admmultiple interactionsEXP 6480464CTDADM protein inhibits the reaction [Letrozole results in decreased expression of AKT1 mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of BCL2 protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of FSHB protein]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PIK3CG mRNA]; ADM protein inhibits the reaction [Letrozole results in decreased expression of PPARG mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of ATF6 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of BAX protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of CCN2 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of DDIT3 mRNA]; ADM protein inhibits the reaction [Letrozole results in increased expression of IL6 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of INS1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TGFB1 protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of TNF protein]; ADM protein inhibits the reaction [Letrozole results in increased expression of XBP1 mRNA]; ADM protein promotes the reaction [Letrozole results in increased expression of ADM protein]PMID:33491863
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