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GENE - TERM ANNOTATION REPORT

RGD ID: 18911552
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Alkbh3
Name: alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
Acc ID: GO:0035516
Term: broad specificity oxidative DNA demethylase activity
Definition: Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA.
Definition Source(s): PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
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