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RGD ID: 18905101
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Acc ID: DOID:9007925
Term: Sudden Cardiac Death
Definition: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
Definition Source(s): MESH:D016757
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hcn4 ISORGD:100446279068941ClinVarClinVar Annotator: match by term: Sudden cardiac death

PMID:21615589, PMID:23623143, PMID:23861362, PMID:24033266, PMID:24569893, PMID:25145517, PMID:25467552, PMID:25642760, PMID:26467025, PMID:28492532
Hcn4 ISORGD:132111579068941ClinVarClinVar Annotator: match by term: Sudden cardiac death

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.