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RGD ID: 18905101
Species: Heterocephalus glaber
RGD Object: Gene
Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Acc ID: DOID:9005141
Term: Ventricular Tachycardia
Definition: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Definition Source(s): MESH:D017180
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hcn4 ISORGD:100461739068941ClinVarClinVar Annotator: match by term: Ventricular tachycardia

PMID:23861362, PMID:25741868, PMID:28492532
Hcn4 ISORGD:110400979068941ClinVarClinVar Annotator: match by term: Ventricular tachycardia

Hcn4 ISORGD:85585169068941ClinVarClinVar Annotator: match by term: Ventricular tachycardia

PMID:19165230, PMID:25741868
Hcn4 ISORGD:86912859068941ClinVarClinVar Annotator: match by term: Ventricular tachycardia

PMID:23861362, PMID:25145518, PMID:25145519, PMID:25642760, PMID:25741868, PMID:26467025, PMID:27173043, PMID:27659478, PMID:28104484, PMID:28182231, PMID:28254189, PMID:28492532
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.