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RGD ID: 18698983
Species: Chlorocebus sabaeus
RGD Object: Gene
Symbol: HCN4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Acc ID: DOID:11984
Term: hypertrophic cardiomyopathy
Definition: A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
Definition Source(s): "DO", "DO", "DO", MESH:D002312
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HCN4 ISORGD:100446369068941ClinVarClinVar Annotator: match by term: Hypertrophic cardiomyopathy

HCN4 ISORGD:113460209068941ClinVarClinVar Annotator: match by term: Hypertrophic cardiomyopathy

HCN4 ISORGD:150149729068941ClinVarClinVar Annotator: match by term: Hypertrophic cardiomyopathy

HCN4 ISORGD:86912859068941ClinVarClinVar Annotator: match by term: Hypertrophic cardiomyopathy

PMID:23861362, PMID:25145518, PMID:25145519, PMID:25642760, PMID:25741868, PMID:26467025, PMID:27173043, PMID:27659478, PMID:28104484, PMID:28182231, PMID:28254189, PMID:28492532
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.