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GENE - TERM ANNOTATION REPORT

RGD ID: 1622319
Species: Mus musculus
RGD Object: Gene
Symbol: Exosc1
Name: exosome component 1
Acc ID: GO:0000176
Term: nuclear exosome (RNase complex)
Definition: A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
Definition Source(s): PMID:17174896, PMID:20531386, PMID:26726035
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Exosc1part_ofNAS 2290270ComplexPortal MGI:6870965 PMID:20531386

MGI:6870965 PMID:20531386
Exosc1part_ofIBAPANTHER:PTN000293867 or SGD:S000005176 or FB:FBgn0032346 or PomBase:SPCC1840.112290270GO_Central GO_REF:0000033
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