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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621553
Species: Mus musculus
RGD Object: Gene
Symbol: Rassf1
Name: Ras association (RalGDS/AF-6) domain family member 1
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rassf1increases response to substanceISORASSF1 (Homo sapiens)6480464CTDRASSF1 results in increased susceptibility to EtoposidePMID:21880625
Rassf1multiple interactionsISORASSF1 (Homo sapiens)6480464CTD[RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein; [RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein; ABT-737 promotes the reaction [RASSF1 results in increased susceptibility to Etoposide]PMID:21880625
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