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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621551
Species: Mus musculus
RGD Object: Gene
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pmaip1increases expressionEXP 6480464CTDHydroxyurea results in increased expression of PMAIP1 mRNAPMID:27208086 PMID:29228353
Pmaip1multiple interactionsEXP 6480464CTDTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of PMAIP1 mRNA]PMID:29228353
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