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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621308
Species: Mus musculus
RGD Object: Gene
Symbol: Acaa1b
Name: acetyl-Coenzyme A acyltransferase 1B
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acaa1baffects expressionEXP 6480464CTDperfluorooctanoic acid affects the expression of ACAA1 mRNAPMID:18281256
Acaa1bincreases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of ACAA1 mRNA; perfluorooctanoic acid results in increased expression of ACAA1B mRNAPMID:17681415 PMID:18467677 PMID:19429403 PMID:20936131 PMID:28558994 PMID:30657992
Acaa1bmultiple interactionsEXP 6480464CTDPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACAA1 mRNA]PMID:18467677
Acaa1bincreases expressionISOAcaa1b (Rattus norvegicus)6480464CTDperfluorooctanoic acid results in increased expression of ACAA1B proteinPMID:34958885
Acaa1bmultiple interactionsISOACAA1 (Homo sapiens)6480464CTDPPARA inhibits the reaction [perfluorooctanoic acid results in increased expression of ACAA1A mRNA]; PPARA inhibits the reaction [perfluorooctanoic acid results in increased expression of ACAA1A protein]PMID:19751795
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