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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620920
Species: Mus musculus
RGD Object: Gene
Symbol: Dnmt3a
Name: DNA methyltransferase 3A
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dnmt3amultiple interactionsISODNMT3A (Homo sapiens)6480464CTD[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]PMID:23626723
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