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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of ABCB1A mRNAPMID:24535843
Abcb1amultiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of ABCB1A mRNAPMID:24535843
Abcb1aincreases expressionISOAbcb1a (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of ABCB1 protein; Diethylnitrosamine results in increased expression of ABCB1A mRNAPMID:11818250 PMID:19638242
Abcb1amultiple interactionsISOAbcb1a (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with Cisplatin] results in increased expression of ABCB1 protein; [Diethylnitrosamine co-treated with Epirubicin] results in increased expression of ABCB1 protein; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCB1A mRNAPMID:11818250 PMID:22129741
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