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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620890
Species: Mus musculus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDfulvestrant results in increased expression of ABCB1 proteinPMID:24685904
Abcb1amultiple interactionsISOAbcb1a (Rattus norvegicus)6480464CTDFulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCB1A mRNA]; Fulvestrant inhibits the reaction [tetrabromobisphenol A results in decreased expression of and results in decreased activity of ABCB1A protein]; Fulvestrant inhibits the reaction [Zearalenone results in increased expression of ABCB1A mRNA]PMID:23707492 PMID:30830211
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCB1 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of ABCB1 protein]PMID:24685904
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