An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID:
MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Doxorubicin results in increased expression of ABCB1 mRNA; Doxorubicin results in increased expression of ABCB1A mRNA; Doxorubicin results in increased expression of ABCB1A protein
[Doxorubicin co-treated with polyisohexylcyanoacrylate] results in increased expression of ABCB1 mRNA; [Doxorubicin co-treated with polyisohexylcyanoacrylate] results in increased expression of ABCB1A mRNA; [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; [Verapamil results in decreased expression of ABCB1] promotes the reaction [Doxorubicin results in increased activity of CASP7 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]; Lipopolysaccharides affects the reaction [ABCB1A protein results in increased secretion of Doxorubicin]; zinc chloride inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 mRNA results in decreased susceptibility to Doxorubicin; ABCB1 promoter modified form results in decreased susceptibility to Doxorubicin; ABCB1 protein results in decreased susceptibility to Doxorubicin; ABCB1 results in decreased susceptibility to Doxorubicin
Doxorubicin results in increased expression of ABCB1; Doxorubicin results in increased expression of ABCB1 mRNA; Doxorubicin results in increased expression of ABCB1 protein
Tamoxifen affects the reaction [ABCB1 protein results in increased secretion of Doxorubicin]; Tamoxifen inhibits the reaction [Doxorubicin affects the activity of ABCB1 protein]
5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; [2-(1-hydroxy-4-oxocyclohexa-2,5-dienyl)pyran-4-one results in increased susceptibility to Doxorubicin] which results in decreased expression of ABCB1 protein; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; [[Resveratrol co-treated with Doxorubicin] results in decreased expression of ABCB1 mRNA] which results in increased uptake of Doxorubicin; [[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin; [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; [ABCB1 protein results in decreased susceptibility to Doxorubicin] inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; [ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]; [Bortezomib co-treated with Doxorubicin] results in decreased expression of ABCB1 protein; [Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]] which results in decreased susceptibility to Doxorubicin; [Carvedilol results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; [Digoxin results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Doxorubicin co-treated with IL6 protein] results in increased expression of ABCB1 protein; [Doxorubicin results in increased expression of ABCB1 protein] which results in decreased susceptibility to Paraquat; [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein; [gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Pentoxifylline co-treated with Doxorubicin] results in decreased expression of ABCB1 protein; [Quercetin co-treated with Doxorubicin] results in decreased expression of ABCB1 protein; [RAB6C protein affects the expression of ABCB1 mRNA] which affects the susceptibility to Doxorubicin; [Resveratrol co-treated with Doxorubicin] results in decreased expression of ABCB1 mRNA; [Resveratrol results in increased susceptibility to Doxorubicin] which results in decreased expression of ABCB1 mRNA; [Resveratrol results in increased susceptibility to Doxorubicin] which results in decreased expression of ABCB1 protein; [Rifampin binds to and results in increased activity of NR1I2 protein] promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Doxorubicin; ABCB1 protein affects the reaction [Doxorubicin results in decreased susceptibility to Paraquat]; ABCB1 protein inhibits the reaction [germacrone results in increased susceptibility to Doxorubicin]; ABCB1 protein inhibits the reaction [Ursolic Acid results in increased susceptibility to Doxorubicin]; ABCB1 protein results in increased export of and results in decreased susceptibility to Doxorubicin; ABCB1 protein results in increased transport of and affects the susceptibility to Doxorubicin; abemaciclib inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Acetaminophen promotes the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Beclomethasone inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; betulin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; CEP 33779 inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Chlorpyrifos inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; CJX1, amlodipine derivative inhibits the reaction [ABCB1 protein results in decreased secretion of Doxorubicin]; Clotrimazole inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Cycloserine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Doxorubicin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Endosulfan inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; fumonisin B1 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; germacrone inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Haloperidol inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; HIF1A protein affects the reaction [[Doxorubicin co-treated with IL6 protein] results in increased expression of ABCB1 protein]; hydramethylnon inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Ivermectin inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; kaempferol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; Ketoconazole inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Lapatinib inhibits the reaction [ABCB1 protein results in increased export of and results in decreased susceptibility to Doxorubicin]; Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Meloxicam inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Mometasone Furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Paliperidone Palmitate inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]; Parathion inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; pluronic block copolymer p85 inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein]; psorospermin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Quercetin inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Risperidone inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]; terameprocol inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; tryptoquivaline inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; valspodar inhibits the reaction [[[Tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased export of Doxorubicin]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Doxorubicin]; Verapamil inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]
