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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620679
Species: Mus musculus
RGD Object: Gene
Symbol: Rdh9
Name: retinol dehydrogenase 9
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rdh9decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of RDH9 mRNA

PMID:19465110, PMID:19770486, PMID:26290441, PMID:28213091
Rdh9multiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of RDH9 mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of RDH9 mRNA, Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to RDH9 gene]

PMID:16214954, PMID:25975270, PMID:28213091
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.