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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620118
Species: Mus musculus
RGD Object: Gene
Symbol: Gsta1
Name: glutathione S-transferase, alpha 1 (Ya)
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsta1increases expressionISOGsta5 (Rattus norvegicus)6480464CTDDiethylnitrosamine results in increased expression of GSTA5 mRNAPMID:19638242 PMID:25242409
Gsta1multiple interactionsISOGsta5 (Rattus norvegicus)6480464CTD[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTA5 mRNA; [Copper co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA; [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTA5 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [isoquercitrin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA]; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA]PMID:18164116 PMID:18253720 PMID:18754104 PMID:18775883 PMID:20033131 PMID:20045035 PMID:20302851 PMID:22129741 PMID:22467020 PMID:22687989
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