GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gstp1 | decreases methylation | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased methylation of GSTP1 promoter | PMID:16613325 | Gstp1 | decreases response to substance | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | GSTP1 protein results in decreased susceptibility to Arsenic Trioxide | PMID:15231573 | Gstp1 | increases expression | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of GSTP1 mRNA | PMID:16613325 | Gstp1 | multiple interactions | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in decreased methylation of GSTP1 promoter] which results in increased expression of GSTP1 mRNA; Arsenic Trioxide promotes the reaction [Decitabine results in increased expression of GSTP1 mRNA]; Arsenic Trioxide results in increased expression of and affects the localization of GSTP1 protein; Decitabine promotes the reaction [Arsenic Trioxide results in increased expression of GSTP1 mRNA]; GSTP1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP3 protein]; GSTP1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of CASP9 protein]; GSTP1 mutant form promotes the reaction [[Arsenic Trioxide co-treated with Ethacrynic Acid] results in increased cleavage of PARP1 protein]; GSTP1 protein results in decreased susceptibility to [Arsenic Trioxide co-treated with Ethacrynic Acid] | PMID:16613325 PMID:23082001 | | ||||||||||||||||||||||
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