GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gstp1 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of GSTP1 mRNA | PMID:14625279 PMID:15034205 PMID:15894712 PMID:21569818 PMID:22228805 | Gstp1 | multiple interactions | EXP | | 6480464 | CTD | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GSTP1 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GSTP1 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSTP1 mRNA; [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GSTP1 mRNA]; AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of GSTP1 mRNA]; Benzo(a)pyrene results in increased expression of and results in increased activity of GSTP1 protein | PMID:14625279 PMID:15034205 PMID:15894712 PMID:25820237 PMID:28987381 PMID:30938511 | Gstp1 | decreases methylation | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of GSTP1 promoter | PMID:27901495 | Gstp1 | decreases response to substance | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | GSTP1 protein results in decreased susceptibility to Benzo(a)pyrene; GSTP1 protein results in decreased susceptibility to Benzo(a)pyrene metabolite; GSTP1 results in decreased susceptibility to Benzo(a)pyrene | PMID:19330882 PMID:2747627 | Gstp1 | increases expression | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of GSTP1 mRNA; Benzo(a)pyrene results in increased expression of GSTP1 protein | PMID:18952161 PMID:20498004 PMID:22316170 | Gstp1 | multiple interactions | ISO | GSTP1 (Homo sapiens) | 6480464 | CTD | Buthionine Sulfoximine inhibits the reaction [GSTP1 results in decreased susceptibility to Benzo(a)pyrene]; GSTP1 protein polymorphism affects the metabolism of and affects the activity of Benzo(a)pyrene | PMID:15298956 PMID:19330882 | | ||||||||||||||||||||||
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