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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620115
Species: Mus musculus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase, pi 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1affects expressionEXP 6480464CTDsodium arsenite affects the expression of GSTP1 mRNAPMID:16507464
Gstp1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of GSTP1 mRNA; sodium arsenite results in increased expression of GSTP1 proteinPMID:14971641 PMID:17451858 PMID:29044176
Gstp1decreases expressionISOGSTP1 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of GSTP1 proteinPMID:33388378
Gstp1decreases response to substanceISOGstp1 (Rattus norvegicus)6480464CTDGSTP1 protein results in decreased susceptibility to sodium arsenitePMID:11455017
Gstp1decreases response to substanceISOGSTP1 (Homo sapiens)6480464CTDGSTP1 protein results in decreased susceptibility to sodium arsenitePMID:18328521
Gstp1increases expressionISOGstp1 (Rattus norvegicus)6480464CTDsodium arsenite results in increased expression of GSTP1 mRNA; sodium arsenite results in increased expression of GSTP1 proteinPMID:11241755 PMID:11455017 PMID:12799770 PMID:16876216 PMID:19933942 PMID:21621526 PMID:23137061 PMID:29459688
Gstp1increases expressionISOGSTP1 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of GSTP1 mRNAPMID:20339138 PMID:34032870
Gstp1increases methylationISOGSTP1 (Homo sapiens)6480464CTDsodium arsenite results in increased methylation of GSTP1 promoterPMID:33388378
Gstp1multiple interactionsISOGstp1 (Rattus norvegicus)6480464CTDVinyl Compounds analog promotes the reaction [sodium arsenite results in increased expression of GSTP1 mRNA]PMID:21621526
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [sodium arsenite results in decreased expression of GSTP1 protein]; Ascorbic Acid inhibits the reaction [sodium arsenite results in increased methylation of GSTP1 promoter]; TET1 protein inhibits the reaction [sodium arsenite results in decreased expression of GSTP1 protein]; TET1 protein inhibits the reaction [sodium arsenite results in increased methylation of GSTP1 promoter]; TET2 protein inhibits the reaction [sodium arsenite results in decreased expression of GSTP1 protein]; TET2 protein inhibits the reaction [sodium arsenite results in increased methylation of GSTP1 promoter]PMID:33388378
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