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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1620115
Species: Mus musculus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase, pi 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of GSTP1 mRNA; Lipopolysaccharides results in increased expression of GSTP1 proteinPMID:16023107
Gstp1multiple interactionsEXP 6480464CTDGSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:16023107
Gstp1increases expressionISOGSTP1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of GSTP1 mRNAPMID:24001438
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTDPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of GSTP1 mRNA]PMID:24001438
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