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GENE - TERM ANNOTATION REPORT

RGD ID: 1619985
Species: Mus musculus
RGD Object: Gene
Symbol: Trmu
Name: tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Acc ID: DOID:0111734
Term: aminoglycoside-induced deafness
Definition: A drug-induced hearing loss characterized by hearing loss induced by therapeutic doses of aminoglycoside antibiotics that has_material_basis_in mutation in the mitochondrial genes MTRNR1 or MTCO1 in combination with homozygous mutation in TRMU on chromosome 22q13.31. (DO)
Definition Source(s): https://www.ncbi.nlm.nih.gov/pubmed/16152638 "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/7689389 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trmu ISOTRMU (Homo sapiens)7240710OMIM  
Trmu ISOTRMU (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Trmu ISOTRMU (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Aminoglycoside-induced deafness | ClinVar Annotator: match by term: Deafness, mitochondrial, modifier ofPMID:16199547 PMID:17576681 PMID:19732863 PMID:21153446 PMID:21169334 PMID:21931168 PMID:23625533 PMID:25665837 PMID:25741868 PMID:26633542 PMID:28049726 PMID:28252636 PMID:28492532 PMID:28973083 PMID:30369941 PMID:30740308 PMID:31160058 PMID:33365252 PMID:33485800 PMID:36305855 PMID:8817331 PMID:9536098
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