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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1619048
Species: Mus musculus
RGD Object: Gene
Symbol: C7
Name: complement component 7
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
C7increases expressionISOC7 (Homo sapiens)6480464CTDNicotine results in increased expression of C7 mRNAPMID:16949557
C7multiple interactionsISOC7 (Homo sapiens)6480464CTDalpha-cobratoxin inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Mecamylamine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]; Tubocurarine inhibits the reaction [Nicotine results in increased expression of C7 mRNA]PMID:16949557
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