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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:9642
Term: N-tosyl-L-phenylalanyl chloromethyl ketone
Definition: The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.
Chemical ID: MESH:D014108
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15multiple interactionsEXP 6480464CTDTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [CPG-oligonucleotide results in increased expression of CXCL8]PMID:22595112
Cxcl15decreases secretionISOCXCL8 (Homo sapiens)6480464CTDTosylphenylalanyl Chloromethyl Ketone results in decreased secretion of CXCL8 proteinPMID:23844176
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTDTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL17A protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]PMID:10540334 PMID:12016129 PMID:12574206 PMID:15139008 PMID:15687330 PMID:21956143
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