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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:51403
Term: 1,4-phenylenediamine
Definition: A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.
Chemical ID: MESH:C029728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15increases expressionEXP 6480464CTD4-phenylenediamine results in increased expression of CXCL15 proteinPMID:34826398
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTD4-phenylenediamine results in increased expression of CXCL8 mRNA; 4-phenylenediamine results in increased expression of CXCL8 proteinPMID:20491607 PMID:20713136 PMID:21920952 PMID:24136171 PMID:25617811 PMID:27965148 PMID:31734321
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTD4-phenylenediamine results in increased secretion of CXCL8 proteinPMID:16099135 PMID:18494145 PMID:34826398
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTDbisindolylmaleimide I affects the reaction [4-phenylenediamine results in increased expression of CXCL8 protein]; MRGPRX2 protein affects the reaction [4-phenylenediamine results in increased secretion of CXCL8 protein]; SB 203580 affects the reaction [4-phenylenediamine results in increased secretion of CXCL8 protein]PMID:18494145 PMID:24136171 PMID:34826398
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