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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:3020
Term: benzalkonium chloride
Definition: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.
Chemical ID: MESH:D001548
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15increases expressionEXP 6480464CTDBenzalkonium Compounds results in increased expression of CXCL5 mRNA; Benzalkonium Compounds results in increased expression of CXCL5 proteinPMID:30171875 PMID:30517752
Cxcl15multiple interactionsEXP 6480464CTD[IL6 protein affects the susceptibility to Benzalkonium Compounds] which affects the expression of CXCL5 mRNAPMID:30171875
Cxcl15decreases expressionISOCXCL8 (Homo sapiens)6480464CTDBenzalkonium Compounds results in decreased expression of CXCL8 mRNA; Benzalkonium Compounds results in decreased expression of CXCL8 proteinPMID:25290854 PMID:28236482 PMID:8006454
Cxcl15decreases secretionISOCXCL8 (Homo sapiens)6480464CTDBenzalkonium Compounds results in decreased secretion of CXCL8 proteinPMID:16099135
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDBenzalkonium Compounds results in increased expression of CXCL8 mRNAPMID:12781210 PMID:20146380 PMID:21920952 PMID:27965148 PMID:28214551 PMID:30806763
Cxcl15increases secretionISOCXCL8 (Homo sapiens)6480464CTDBenzalkonium Compounds results in increased secretion of CXCL8 proteinPMID:12781210 PMID:17763283 PMID:19729060
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