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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15increases expressionEXP 6480464CTDarsenite results in increased expression of CXCL5 mRNAPMID:18929588
Cxcl15multiple interactionsEXP 6480464CTDTRP53 protein affects the reaction [arsenite results in increased expression of CXCL5 mRNA]PMID:18929588
Cxcl15affects expressionISOCXCL8 (Homo sapiens)6480464CTDarsenite affects the expression of CXCL8 mRNAPMID:22959463
Cxcl15decreases expressionISOCXCL8 (Homo sapiens)6480464CTDarsenite results in decreased expression of CXCL8 mRNAPMID:16085347
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDarsenite results in increased expression of CXCL8 mRNA; arsenite results in increased expression of CXCL8 proteinPMID:18418899 PMID:25257954
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTD[arsenite results in increased activity of [NFKB1 protein binds to RELB protein]] which results in increased expression of CXCL8 mRNA; arsenite inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; arsenite promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]; arsenite promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]; caffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of CXCL8 mRNA]PMID:10775461 PMID:16085347 PMID:18418899 PMID:25680285
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