GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cxcl15 | decreases degradation | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | deoxynivalenol results in decreased degradation of CXCL8 mRNA | PMID:18485432 | Cxcl15 | increases expression | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | [deoxynivalenol results in increased expression of EGR1 protein] which results in increased expression of CXCL8 protein; deoxynivalenol results in increased expression of CXCL8 mRNA; deoxynivalenol results in increased expression of CXCL8 protein | PMID:16364386 PMID:17166736 PMID:17636245 PMID:17707346 PMID:18308354 PMID:18485432 PMID:18599499 PMID:19591856 PMID:20181660 PMID:20633634 PMID:22003189 PMID:23792671 PMID:27757495 PMID:32065293 PMID:35314294 | Cxcl15 | increases secretion | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | deoxynivalenol results in increased secretion of CXCL8 mRNA; deoxynivalenol results in increased secretion of CXCL8 protein | PMID:20633634 PMID:23792671 PMID:32065293 PMID:33170220 PMID:37315771 | Cxcl15 | multiple interactions | ISO | CXCL8 (Homo sapiens) | 6480464 | CTD | 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in decreased degradation of CXCL8 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased secretion of CXCL8 protein]; 2-Aminopurine inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; 2-Aminopurine inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; 2-chloro-5-nitrobenzanilide promotes the reaction [deoxynivalenol results in decreased degradation of CXCL8 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL8 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; [deoxynivalenol results in increased expression of ELAVL1 protein] which results in decreased degradation of CXCL8 mRNA; [deoxynivalenol results in increased phosphorylation of MAPK1 protein] which results in increased expression of CXCL8 protein; [deoxynivalenol results in increased phosphorylation of MAPK3 protein] which results in increased expression of CXCL8 protein; Adenine inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; AG 1879 inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; cereulide inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; cereulide inhibits the reaction [deoxynivalenol results in increased secretion of CXCL8 protein]; Cycloheximide inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; Dactinomycin inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; deoxynivalenol inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; deoxynivalenol inhibits the reaction [NFKB2 protein binds to CXCL8 promoter]; deoxynivalenol promotes the reaction [RELA protein binds to CXCL8 promoter]; EIF2AK2 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL8 mRNA]; ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; ELAVL1 protein affects the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; GW 506033X inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; GW 506033X inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; PPARG protein affects the reaction [deoxynivalenol results in decreased degradation of CXCL8 mRNA]; prolinedithiocarbamate inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; RELA protein promotes the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased secretion of CXCL8 protein]; triptolide inhibits the reaction [deoxynivalenol results in increased secretion of CXCL8 protein] | PMID:16364386 PMID:17636245 PMID:17707346 PMID:18308354 PMID:18485432 PMID:18599499 PMID:19591856 PMID:20181660 PMID:20633634 PMID:22003189 PMID:32065293 PMID:37315771 | | ||||||||||||||||||||||
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