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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616839
Species: Mus musculus
RGD Object: Gene
Symbol: Eif2ak2
Name: eukaryotic translation initiation factor 2-alpha kinase 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak2increases phosphorylationISOEIF2AK2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of EIF2AK2 proteinPMID:29486283
Eif2ak2multiple interactionsISOEIF2AK2 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [MSI1 protein binds to EIF2AK2 protein modified form]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of MYC protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of KLF4 protein]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of MYC protein]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of POU5F1 protein]; EIF2AK2 protein affects the reaction [Arsenic Trioxide results in increased expression of SOX2 protein]; EIF2AK2 protein affects the reaction [MSI1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]]; EIF2S1 protein affects the reaction [MSI1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein]]; MSI1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein]PMID:29486283
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