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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616546
Species: Mus musculus
RGD Object: Gene
Symbol: Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2cmultiple interactionsISOKMT2C (Homo sapiens)6480464CTD[Diethylstilbestrol promotes the reaction [KMT2C protein binds to HOTAIR promoter]] which results in increased expression of HOTAIR mRNA; Diethylstilbestrol promotes the reaction [KMT2C protein binds to EZH2 promoter]; Diethylstilbestrol promotes the reaction [KMT2C protein binds to HOTAIR promoter]; KMT2C mutant form inhibits the reaction [Diethylstilbestrol results in increased expression of EZH2 mRNA]PMID:24533973 PMID:25088689
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