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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616546
Species: Mus musculus
RGD Object: Gene
Symbol: Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2cdecreases expressionISOKMT2C (Homo sapiens)6480464CTDNicotine results in decreased expression of KMT2C mRNAPMID:12588870
Kmt2cmultiple interactionsISOKMT2C (Homo sapiens)6480464CTDalpha-cobratoxin inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Mecamylamine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of KMT2C mRNA]PMID:12588870
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