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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616012
Species: Mus musculus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle, aorta
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2decreases expressionISOActa2 (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of ACTA2 proteinPMID:29775649
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of ACTA2 proteinPMID:31935363
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTD2,5-dimethyl-4-benzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]; 2-tert-butyl-4-quinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]; phenylbenzoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of ACTA2 protein]PMID:31935363
Acta2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTD[sodium arsenite co-treated with Lipopolysaccharides] results in increased expression of ACTA2 mRNA; [sodium arsenite co-treated with Lipopolysaccharides] results in increased expression of ACTA2 protein; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[sodium arsenite co-treated with Lipopolysaccharides] results in increased expression of ACTA2 protein]; SERPINH1 protein promotes the reaction [[sodium arsenite co-treated with Lipopolysaccharides] results in increased expression of ACTA2 mRNA]PMID:35963424
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