GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Fasn | increases expression | EXP | | 6480464 | CTD | Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein | PMID:15066988 PMID:22698815 PMID:27531227 PMID:28123933 PMID:28257781 | Fasn | multiple interactions | EXP | | 6480464 | CTD | FGF21 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Phenylbutyrates inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Plant Preparations inhibits the reaction [Fructose results in increased expression of FASN protein]; SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Triolein inhibits the reaction [SCD1 gene mutant form inhibits the reaction [Fructose results in increased expression of FASN mRNA]]; Triolein promotes the reaction [Fructose results in increased expression of FASN mRNA] | PMID:15066988 PMID:22698815 PMID:27531227 PMID:28123933 | Fasn | increases activity | ISO | Fasn (Rattus norvegicus) | 6480464 | CTD | Fructose results in increased activity of FASN protein | PMID:8759368 PMID:9566986 | Fasn | increases expression | ISO | Fasn (Rattus norvegicus) | 6480464 | CTD | Fructose results in increased expression of FASN mRNA; Fructose results in increased expression of FASN protein | PMID:12065722 PMID:18346472 PMID:19053045 PMID:19193814 PMID:19196556 PMID:21781943 PMID:26973390 PMID:31661889 PMID:8759368 PMID:9566986 | Fasn | multiple interactions | ISO | FASN (Homo sapiens) | 6480464 | CTD | [Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein] | PMID:32730863 | Fasn | multiple interactions | ISO | Fasn (Rattus norvegicus) | 6480464 | CTD | [Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; [Copper deficiency co-treated with Fructose] results in increased expression of FASN protein; [Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; [Fructose co-treated with Dietary Fats] results in increased expression of FASN protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; bisphenol A promotes the reaction [Fructose results in increased expression of FASN mRNA]; bisphenol A promotes the reaction [Fructose results in increased expression of FASN protein]; dapagliflozin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Resveratrol inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Rosiglitazone inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Tea inhibits the reaction [Fructose results in increased expression of FASN mRNA] | PMID:19193814 PMID:19196556 PMID:21781943 PMID:25813056 PMID:26973390 PMID:31661889 PMID:32259528 | | ||||||||||||||||||||||
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